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Apr 30, 2024 · Propofol-related infusion syndrome ( PRIS ) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly Propofol infusion syndrome ( PRIS ) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Background PRIS = propofol infusion syndrome Refractory bradycardia and cardiovascular collapse Poorly understood mechanism Risk factors High doses of (> 4mg kg hr or 67 mcg kg min) Long duration (> 48 hrs) Younger age ( PRIS first recognized in pediatric population) Critical illness Malnutrition Liver disease Carnitine deficiency Mitochondrial Propofol infusion syndrome ( PRIS ) is defined as an uncommon but potentially fatal condition that can occur in patients receiving prolonged propofol infusions, characterized by severe manifestations such as cardiac failure, rhabdomyolysis, metabolic acidosis, renal failure, and death Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease Propofol-related Infusion Syndrome ( PRIS ) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of: 2 days ago · The Power Reactor Information System ( PRIS ), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide Propofol-related infusion syndrome ( PRIS ) is a lethal condition characterized by multiple organ system failures It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients The term PRIS —propofol infusion syndrome— was originally coined by Bray in 1998 to de-scribe the adverse effects associated with the use of propofol in the paediatric population If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS
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