Various criteria, including the underlying cause of insomnia, medical history, and possible side effects, determine which sleep pill is ideal for each person. Medicines that increase the effects of GABA to promote sleep, such as benzodiazepines like temazepam and non-benzodiazepine sedative-hypnotics like zolpidem, are often recommended. However, long-term usage of these pills increases the danger of tolerance and dependency. Orexin receptor antagonists like suvorexant and melatonin agonists like ramelteon provide alternative modes of action with fewer negative effects. In cases where co-occurring mood disorders are present, antidepressants such as trazodone may be administered off-label to treat insomnia. When choosing the appropriate sleep aid, patients should speak with a healthcare professional to assess the advantages and disadvantages of each option depending on their unique requirements and circumstances. Non-pharmacological options, such as cognitive-behavioral treatment for insomnia (CBT-I), are often taken into account. Visit: Medzsquare